Computational modelling, green synthesis and biological activity of arylsulfonilamides as NNRTIs against HIV-1
نویسندگان
چکیده
Methods Development of arylsulfonilamides as NNRTIs involved both the computational and synthetic methods. On the basis of extensive docking experiments, ten promising compounds out of 55 initially taken were synthesized using green protocols and their in vitro anti-HIV activity assessed in TZM bl cells by luciferase assay and reverse transcriptase (RT) inhibition assay against wild type HIV-1 RT.
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